5 Facts you should know about

Progressive Familial Intrahepatic Cholestasis (PFIC)

Affected individuals experience severe itching, jaundice, portal hypertension, and hepatosplenomegaly

The hallmark feature of this disorder is severe debilitating pruritus

Pruritus is often out of proportion to the level of jaundice

Pruritus may be hard to identify in young babies because they have difficulty scratching. Instead, they may be irritable and sleep poorly

Scratching in babies often starts as digging at the ears and eyes, which are the first areas to show bleeding and scarring

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