5 Facts you should know about

Gilbert syndrome

Gilbert syndrome is a common, benign, and usually inherited condition characterized by mild unconjugated hyperbilirubinemia, leading to elevated levels of bilirubin in the blood, primarily unconjugated bilirubin

It is caused by a genetic variation affecting the UGT1A1 gene, responsible for producing an enzyme called UDP-glucuronosyltransferase, crucial for bilirubin metabolism and excretion

Individuals with Gilbert syndrome may experience intermittent jaundice, often triggered by factors like fasting, dehydration, stress, or illness, but typically do not have any other symptoms or liver abnormalities

Diagnosis involves clinical evaluation, blood tests showing elevated unconjugated bilirubin levels without signs of liver disease or hemolysis, and sometimes genetic testing to confirm the presence of specific UGT1A1 gene variations

Treatment is generally unnecessary for Gilbert syndrome as it does not cause significant health problems; however, avoiding triggers and maintaining a healthy lifestyle can help manage occasional jaundice episodes

See our full disease profile

Rare Gastroenterology News